About PreDx® DRS

Meeting the unmet need

There are a number of well-known risk factors designated by the American Diabetes Association22 for the development of type 2 diabetes, including higher-than-normal HbA1c and fasting plasma glucose levels, metabolic syndrome and obesity. However, no single risk factor reliably discriminates between those who will develop the disease and those who will not.

Consider the challenge facing primary care clinicians today: Of the 226 million US adults, 79 million have impaired fasting glucose and/or elevated HbA1c levels, and are therefore considered to be at increased risk for type 2 diabetes.23 However, only a small percentage of these patients will develop diabetes within the next five years.24 How do you, as a primary care clinician, find those patients who are in greatest need of early and aggressive intervention strategies?

The PreDx Diabetes Risk Score

Diabetes Risk Score

Your patient's score and risk level appear on the colored scale of the PreDx DRS report.

The Science of PreDx DRS: Assessing the underlying pathophysiology of diabetes progression

Steven Watkins, PhD, CTO
Tethys Bioscience

The PreDx Diabetes Risk Score (DRS) is a simple fasting blood test that determines your patient’s absolute risk of developing type 2 diabetes within 5 years.

  • Measures multiple serum biomarkers associated with biological pathways implicated in the development and progression of type 2 diabetes.
  • Utilizes a complex algorithm based on the quantification of these markers to produce a personalized risk score on a scale of 1 (lower risk) to 10 (highest risk) that correlates with an individual’s absolute risk of developing diabetes within 5 years.
  • Independently validated in the Inter99 cohort, a population-based lifestyle intervention study for cardiovascular disease in adults.
  • Further evaluated in independent populations, the Botnia cohort and a multiethnic population, the IRAS study.26,27

 


Early intervention is key to prevention

Michael AbouAssaly, MD

PreDx DRS benefits lead to more effective patient management

The PreDx DRS enables you to more confidently differentiate those patients who are at highest risk of developing type 2 diabetes within the next five years from those at lower risk. With this information, you can focus interventions on the relatively few patients who are at more imminent risk of conversion.

 

Whom to test

Physicians use PreDx DRS to further stratify at-risk patients

Uday Jani, MD

The PreDx DRS is indicated for use in patients who are at increased risk for developing type 2 diabetes, and is not intended for use in individuals already diagnosed with diabetes.

Consider the PreDx DRS for your patients with impaired fasting glucose, metabolic syndrome, and other risk factors, including:28

  • Agre greater than 45 years
  • Hypertension
  • Coronary artery disease
  • Obesity
  • Family history of diabetes
  • Elevated triglycerides
  • HDL cholesterol under 35 mg/dL
  • Sedentary lifestyle
  • African American, Hispanic, Asian or Native American ethnicity